Webinar Recording

During this webinar, we will discuss the following key points:

  • ADAM17 functions as a negative regulatory checkpoint in NK cells and is a tumor-associated antigen
  • Development of the multi-engager antibody complex Targeted ADAM17 Blocker and Killer (TABK)
  • TABK selectively blocks ADAM17 in NK cells and synergizes with IL-15 stimulation to enhance NK cell activation and proliferation
  • TABK engages ADAM17 overexpressed by various malignancies, linking NK cells to tumor cells to mediate their killing
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