Therapeutic VHHs

Potential targets for VHH include cell surface proteins, cytokines, secreted proteins, intracellular proteins, etc. Depending on the targets, the therapeutic effects of VHHs can be mediated by different mechanisms, including but not limited to:

  • Neutralization of toxins, viruses, and cytokines
  • Blocking of ligand-receptor interaction, blocking of apoptotic pathways, or blocking blood clotting
  • Preventing aberrant protein aggregation
  • Activation of T cells and natural killer (NK) cells to target and destroy tumor cells
  • Crossing the blood-brain barrier
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